Cstb Company Profile

Aggregated data from the web about Cstb

Company Name	Cstb
Website	https://medlineplus.gov
Snippet	The CSTB gene provides instructions for making a protein called cystatin B. This protein reduces the activity of (inhibits) enzymes called cathepsins. Cathepsins help break down certain proteins in the lysosomes (compartments in the cell that digest and recycle materials). While the specific function of cystatin B is unclear, it may help protect ...
End	78,427,622 bp[2]
PDB	Ortholog search: PDBe RCSB
Band	10 C1\|10 39.72 cM
Chr.	Chromosome 10 (mouse)[2]
Entrez	1476
Aliases	CSTB, CST6, EPM1, EPM1A, PME, STFB, ULD, Cystatin B, CPI-B
Ensembl	ENSG00000160213
Species	Human
UniProt	P04080
External IDs	OMIM: 601145 MGI: 109514 HomoloGene: 79 GeneCards: CSTB
Gene ontology	Gene ontologyMolecular function• peptidase inhibitor activity• protease binding• endopeptidase inhibitor activity• cysteine-type endopeptidase inhibitor activity• RNA bindingCellular component• cytoplasm• nucleolus• extracellular exosome• intracellular• cell nucleus• extracellular region• extracellular• cytosol• secretory granule lumen• tertiary granule lumen• ficolin-1-rich granule lumen• collagen-containing extracellular matrixBiological process• adult locomotory behavior• negative regulation of proteolysis• negative regulation of peptidase activity• negative regulation of endopeptidase activity• neutrophil degranulationSources:Amigo / QuickGO
PubMed search	[3]
RefSeq (mRNA)	NM_000100
Location (UCSC)	Chr 21: 43.77 – 43.78 Mb
RefSeq (protein)	NP_000091
Biological process	• adult locomotory behavior• negative regulation of proteolysis• negative regulation of peptidase activity• negative regulation of endopeptidase activity• neutrophil degranulation
Cellular component	• cytoplasm• nucleolus• extracellular exosome• intracellular• cell nucleus• extracellular region• extracellular• cytosol• secretory granule lumen• tertiary granule lumen• ficolin-1-rich granule lumen• collagen-containing extracellular matrix
Molecular function	• peptidase inhibitor activity• protease binding• endopeptidase inhibitor activity• cysteine-type endopeptidase inhibitor activity• RNA binding
Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1STF, 2OCT, 4N6V
List of PDB id codes	List of PDB id codes1STF, 2OCT, 4N6V
Gene location (Human)	Gene location (Human)Chr.Chromosome 21 (human)[1]Band21q22.3Start43,772,511 bp[1]End43,776,330 bp[1]
Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 10 (mouse)[2]Band10 C1\|10 39.72 cMStart78,425,669 bp[2]End78,427,622 bp[2]
RNA expression pattern	RNA expression patternMore reference expression data

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